Hyperdry Human Amniotic Membrane (HD-AM) is Supporting Aciclovir Included Device of Poly-N-p-Vinyl-Benzyl-D-Lactonamide (PVLA) Sphere for Treatment of HSV-1 Infected Rabbit Keratitis Model

Herpes simplex virus (HSV) is one of the main infectious causes of corneal blindness worldwide. A variety of clinical manifestations of both infectious and immunologic diseases affects all levels of the cornea in HSV keratitis. Acyclovir (ACV) is the main therapeutic regime for corneal ulcer because HSV-1is sensitive to ACV . The common regimen for corneal herpes in Japan is administration of ACV eye ointment (ACV-O). However, because ACV-O must be administered 5 times daily and shows poor water solubility and thus low bioavailability, alternative delivery approaches are needed to increase the therapeutic potential of ACV.

Poly-N-p-vinylbenzyl-D-lactonamide (PVLA) is a superior surface-coating material for culturing hepatocyte; it adheres to hepatocytes through a highly specific interaction between its galactose moiety and cell surface asialoglycoprotein receptors. PVLA has been shown to form polymeric micelles in water because of the presence of a hydrophobic polystyrene backbone and hydrophilic sugar moieties. A saline solution containing PVLA may be an effective solvent for ACV.(Read more)