Role of Mucosal Colonic Biopsy in Patients with Chronic Unexplained Diarrhoea who their Colonoscopy is Normal.

Chronic diarrhoea is one of the most common conditions presented to a gastroenterologist. It may be defined as the passage of abnormally liquid or unformed stools at an increased frequency as stool weight ≥ 200 g/day and duration is ≥ 4 weeks. It has varied etiology like infections, inflammatory bowel disease, neoplasia,diverticular disease, endocrine-metabolic, functional, drug induced or as a side effect of radiation therapy. Thus the diagnosis of chronic diarrhoea is complex.

Colonscopy is one of the most important tools for investigation of colorectal diseases as it has been used to screen large bowel to identify early lesions in many risk groups and to investigate patients with various complains as abdominal pain, changes in bowel habits, gastrointestinal bleeding, chronic diarrhoea and abdominal masses.(Read More)